Esketamine For Depression

In early 2019, the FDA approved Spravato™, an esketamine nasal spray designed to relieve treatment-resistant depression. Beaches TMS & Brain Health offers Spravato treatment to help you alleviate your depression symptoms and restore your quality of life. If you’re struggling with treatment-resistant depression, call TMS & Brain Health or request an appointment online today to find out how Spravato can help you.

What is SPRAVATO® ?

SPRAVATO® is an esketamine nasal spray that is used in combination with an oral antidepressant. SPRAVATO® can alleviate the symptoms of treatment-resistant depression and Major Depressive Disorder (MDD) with suicidal ideation. Ketamine is a chemical which consists of two mirror-image molecules, S-ketamine and R-ketamine. When used as an anesthetic or in an intravenous infusion, both the S and R molecules are included. However, SPRAVATO® only uses the S molecule. For more information please visit https://www.spravato.com/.

SPRAVATO® Treatment at Beaches TMS & Brain Health

Prior to beginning treatment, our office will conduct a comprehensive evaluation to determine if SPRAVATO® is the best option for you.

SPRAVATO® is prescribed in one of two dosages: 56mg or 84mg. The first treatment will always be 56mg. During treatment, you will rest comfortably under the supervision of a certified SPRAVATO® specialist for approximately 2 hours. SPRAVATO® can trigger some short- lived side effects such as dizziness, dissociation, and sedation. These side effects usually happen right after taking SPRAVATO® and go away the same day. Once the provider has released you, you will need a friend or family member to drive you home.

The usual SPRAVATO® treatment plan consist of:

Month 1: Two treatments per week
Month 2: One treatment per week
Month 3+: Continue weekly treatment Or Treatment once every 2 weeks

To speak with a representative about your options, call our office today or request an appointment using our online scheduling tool, and a representative will reach out to you!

How to Get started with SPRAVATO® therapy at Beaches TMS & Brain Health

If it sounds like Spravato® may be a feasible option for you, please contact your healthcare provider.

  1. Request SPRAVATO® / Esketamine Consult.
  2. Become a patient.
  3. Insurance verification and pre-authorization.
  4. Schedule first treatment

Frequently Asked Questions

What is treatment Resistant Depression?
In the SPRAVATO® clinical trials, treatment-resistant depression was diagnosed in adults who were struggling with major depressive disorder and had not responded adequately to at least two different antidepressants of adequate dose and duration in the current depressive episode.
 
How is Spravato nasal spray different than ketamine infusion?
SPRAVATO® (esketamine) CIII nasal spray is a derivative of ketamine. SPRAVATO® is an FDA-approved nasal spray for treatment-resistant depression; it is also approved to treat depressive symptoms in adults with major depressive disorder with suicidal thoughts or actions. Ketamine has not been approved by the FDA to treat depression. Both SPRAVATO® and ketamine are Schedule III controlled substances under the US Controlled Substances Act.
 
What personal items can I bring to my treatment session?
You can bring personal items that make you feel comfortable which may include headphones, a music player, a tablet, crossword puzzles or a book to pass the time, and a blanket and pillow to help you relax.
 

What happens during the observation period after taking SPRAVATO®?

The observation period begins right after the treatment is administered. During this time patients will be allowed to rest comfortably and will be monitored by a healthcare provider for any side effects you may experience. You should expect your healthcare provider to ask you about the side effects and have your blood pressure taking periodically during the observation period.
 
What side effects could I experience on SPRAVATO®?

Other possible serious side effects include increased blood pressure, problems with thinking clearly, and bladder problems. The most common side effects include feeling disconnected from yourself, your thoughts, feelings, and things around you (dissociation); dizziness; nausea; feeling sleepy (sedation); spinning sensation; decreased feeling of sensitivity (numbness); feeling anxious; lack of energy; increased blood pressure; vomiting; feeling drunk; and feeling very happy or excited.

Serious side effects reported with SPRAVATO® include sedation and dissociation, and there is a risk of abuse and misuse with SPRAVATO®. There is an increased risk of suicidal thoughts and behavior with SPRAVATO®. Call your healthcare provider right away if you have new or sudden changes in mood, behavior, thoughts, or feelings, or if you develop suicidal thoughts or behavior.

Because of the possibility of nausea and vomiting, you should avoid eating two hours before, and drinking liquids 30 minutes before, taking SPRAVATO®.
 
How quickly might I see improvements in depressive symptoms with Spravato for treatment-resistant depression
In clinical studies, improvement of depressive symptoms was demonstrated at four weeks by SPRAVATO® plus an oral antidepressant, compared with placebo nasal spray plus an oral antidepressant. Not all patients will respond to SPRAVATO®.
 
What should I tell my healthcare provider before starting Spravato?

Other possible serious side effects include increased blood pressure, problems with thinking clearly and bladder problems. The most common side effects include feeling disconnected from yourself, your thoughts, feelings and things around you (dissociation); dizziness; nausea; feeling sleepy (sedation); spinning sensation; decreased feeling of sensitivity (numbness); feeling anxious; lack of energy; increased blood pressure; vomiting; feeling drunk; and feeling very happy or excited.

Serious side effects reported with SPRAVATO® include sedation and dissociation, and there is a risk of abuse and misuse with SPRAVATO®. There is an increased risk of suicidal thoughts and behavior with SPRAVATO®.

Call your healthcare provider right away if you have new or sudden changes in mood, behavior, thoughts, or feelings, or if you develop suicidal thoughts or behavior. Because of the possibility of nausea and vomiting, you should avoid eating two hours before, and drinking liquids 30 minutes before, taking SPRAVATO®.
 
How quickly might I see improvements of depressive symptoms with SPRAVATO® for treatment-resistant depression?
In clinical studies, improvement of depressive symptoms was demonstrated at four weeks by SPRAVATO® plus an oral antidepressant, compared with placebo nasal spray plus an oral antidepressant. Not all patients will respond to SPRAVATO®.
 
What should I tell my healthcare provider before starting Spravato®?
Before starting, tell your healthcare provider about your full medication and depression treatment history, including if you have a history abusing prescription or street drugs, or a problem with alcohol. Do not take SPRAVATO® if you have: a blood vessel disease (aneurysm), an abnormal connection between your blood vessels (arteriovenous malformation), a history of bleeding in the brain or if you are allergic to esketamine, ketamine or any of the ingredients in SPRAVATO®. Be sure to tell your healthcare provider if you have heart, brain or liver problems; if you have psychosis; or if you are pregnant, planning to become pregnant, breastfeeding or planning to breastfeed. You should not take SPRAVATO® if you are pregnant. You should not breastfeed if you are taking SPRAVATO®.

Tell your healthcare provider about all the medicines that you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

For more FAQ’s about Spravato®, please visit: https://www.spravato.com/trd/faqs.

Office Information

Address:
1909 Beach Boulevard, Suite 201 Jacksonville Beach, FL 32250

Phone: 
(904) 853-8567

Fax: 
(904) 853-5885

Email:
tms@beachesbehavioral.com

Questions?

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